British cosmologist Stephen William Hawking was born in Oxford, England on Jan. 8, 1942 - 300 years to the day after the death of the astronomer Galileo Galilei. He attended University College, Oxford, where he studied physics, despite his father's urging to focus on medicine. Hawking went on to Cambridge to research cosmology, the study of the universe as a whole.

In early 1963, just shy of his 21st birthday, Hawking was diagnosed with motor neuron disease, more commonly known as Lou Gehrig's disease or amyotrophic lateral sclerosis (ALS). Doctors told Hawkings that he would likely not survive more than two years with the disease. Completing his doctorate did not appear likely, but Hawking defied the odds. He also obtained his PhD in 1966 for his thesis entitled "Properties of expanding universes". In that same year, Hawking also won the prestigious Adams Prize for his essay entitled "Singularities and the Geometry of Space-Time".

From then Hawking went on to forge new roads into the understanding of the universe in the decades since.

As the disease spread, Hawking became less mobile and began using a wheelchair. Talking grew more challenging and, in 1985, an emergency tracheotomy caused his total loss of speech. A speech-generating device constructed at Cambridge, combined with a software program, served as his electronic voice, allowing Hawking to select his words by moving the muscles in his cheek.

Just before his diagnosis, Hawking met Jane Wilde, and the two were married in 1965. The couple had three children before separating in 1990. Hawking remarried in 1995 to Elaine Mason but divorced in 2006.